Lilian U Thompson Selected Research

2,3-bis(3'-hydroxybenzyl)butyrolactone (enterolactone)

1/2019	Genetic Variation in Steroid and Xenobiotic Metabolizing Pathways and Enterolactone Excretion Before and After Flaxseed Intervention in African American and European American Women.
7/2007	Can the combination of flaxseed and its lignans with soy and its isoflavones reduce the growth stimulatory effect of soy and its isoflavones on established breast cancer?
2/2007	Flaxseed and its lignans inhibit estradiol-induced growth, angiogenesis, and secretion of vascular endothelial growth factor in human breast cancer xenografts in vivo.
7/2006	Genistein alone and in combination with the mammalian lignans enterolactone and enterodiol induce estrogenic effects on bone and uterus in a postmenopausal breast cancer mouse model.
4/2006	Sesamin is one of the major precursors of mammalian lignans in sesame seed (Sesamum indicum) as observed in vitro and in rats.
3/2006	Mammalian lignans enterolactone and enterodiol, alone and in combination with the isoflavone genistein, do not promote the growth of MCF-7 xenografts in ovariectomized athymic nude mice.
4/2005	Mammalian lignans and genistein decrease the activities of aromatase and 17beta-hydroxysteroid dehydrogenase in MCF-7 cells.
7/2003	Lignans and tamoxifen, alone or in combination, reduce human breast cancer cell adhesion, invasion and migration in vitro.

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Lilian U Thompson Research Topics

Disease

49	Breast Neoplasms (Breast Cancer) 06/2022 - 01/2002
33	Neoplasms (Cancer) 11/2019 - 01/2002
6	Body Weight (Weight, Body) 09/2012 - 03/2006
5	Carcinogenesis 01/2015 - 09/2003
5	Neoplasm Metastasis (Metastasis) 03/2006 - 01/2002
3	Postmenopausal Osteoporosis 09/2012 - 05/2009
2	Chronic Disease (Chronic Diseases) 03/2021 - 02/2004
1	Lipoma (Lipomata) 01/2015
1	Bone Resorption 07/2014
1	Adenocarcinoma 02/2011
1	Overweight 04/2008
1	Hyperlipidemias (Hyperlipidemia) 05/2006

Drug/Important Bio-Agent (IBA)

32	LignansIBA 03/2021 - 01/2002
21	Estrogens (Estrogen)FDA Link 01/2019 - 02/2004
15	Estrogen ReceptorsIBA 01/2018 - 01/2002
13	Phytoestrogens (Phytoestrogen)IBA 01/2019 - 11/2002
10	Tamoxifen FDA LinkGeneric 06/2014 - 07/2003
8	secoisolariciresinol diglucosideIBA 11/2019 - 02/2004
8	2,3-bis(3'-hydroxybenzyl)butyrolactone (enterolactone)IBA 01/2019 - 07/2003
8	IsoflavonesIBA 03/2013 - 04/2005
7	Linseed Oil (Flaxseed Oil)IBA 01/2018 - 03/2006
7	alpha-Linolenic Acid (Linolenic Acid)IBA 01/2018 - 01/2002
7	2,3-bis(3'-hydroxybenzyl)butane-1,4-diol (enterodiol)IBA 07/2007 - 07/2003
6	Biomarkers (Surrogate Marker)IBA 06/2022 - 05/2005
6	Estradiol (Delestrogen)FDA LinkGeneric 09/2012 - 04/2005
5	Hormones (Hormone)IBA 01/2019 - 01/2006
5	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 10/2010 - 09/2007
4	Trastuzumab (Herceptin)FDA Link 08/2015 - 08/2010
4	Omega-3 Fatty Acids (Omega 3 Fatty Acids)IBA 08/2015 - 01/2010
4	Soybean Proteins (Soy Protein)IBA 11/2008 - 08/2006
4	GenisteinIBA 07/2007 - 04/2005
3	Fatty Acids (Saturated Fatty Acids)IBA 08/2015 - 05/2009
3	Proteins (Proteins, Gene)FDA Link 01/2015 - 10/2003
3	Progesterone Receptors (Progesterone Receptor)IBA 01/2012 - 05/2005
3	secoisolariciresinolIBA 10/2011 - 09/2005
3	ErbB Receptors (EGF Receptor)IBA 08/2010 - 01/2002
3	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 03/2010 - 11/2002
3	Estrogen Receptor alphaIBA 11/2008 - 10/2003
2	MicroRNAs (MicroRNA)IBA 11/2019 - 01/2018
2	SteroidsIBA 01/2019 - 01/2014
2	Docosahexaenoic AcidsIBA 01/2018 - 08/2015
2	Pharmaceutical PreparationsIBA 08/2015 - 08/2010
2	Phenobarbital (Luminal)FDA Link 01/2015 - 01/2015
2	Mitogen-Activated Protein KinasesIBA 01/2015 - 03/2010
2	LigandsIBA 07/2014 - 10/2003
2	human ERBB2 proteinIBA 01/2013 - 03/2010
2	antineoplaston A10 (A 10)IBA 10/2011 - 04/2006
2	TritiumIBA 10/2011 - 01/2008
2	Folic Acid (Vitamin M)FDA LinkGeneric 02/2011 - 07/2009
2	Cyclin D1IBA 03/2010 - 11/2008
2	Estrogen Receptor betaIBA 11/2008 - 10/2003
2	Insulin-Like Growth Factor I (IGF-1)IBA 09/2007 - 01/2002
1	PhytochemicalsIBA 03/2021
1	Gonadal Steroid Hormones (Sex Hormones)IBA 01/2019
1	XenobioticsIBA 01/2019
1	Eicosapentaenoic AcidIBA 01/2018
1	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 01/2018
1	Phospholipids (Phosphatides)FDA LinkGeneric 08/2015
1	Messenger RNA (mRNA)IBA 01/2015
1	AcidsIBA 01/2015
1	OsteocalcinIBA 07/2014
1	OsteoprotegerinIBA 07/2014
1	Tartrate-Resistant Acid PhosphataseIBA 07/2014
1	Aromatase InhibitorsIBA 01/2014
1	Anastrozole (Arimidex)FDA LinkGeneric 01/2014
1	Progesterone FDA LinkGeneric 03/2013
1	anthraceneIBA 02/2011
1	MethyltransferasesIBA 02/2011
1	DNA (Deoxyribonucleic Acid)IBA 02/2011
1	Trefoil Factor-1IBA 03/2010
1	Somatomedin Receptors (Somatomedin Receptor)IBA 03/2010
1	Tumor Biomarkers (Tumor Markers)IBA 11/2008
1	CarbohydratesIBA 05/2006
1	sesaminIBA 04/2006
1	Malondialdehyde (Propanedial)IBA 09/2005
1	Aromatase (CYP19)IBA 04/2005
1	EnzymesIBA 04/2005
1	Estrogen Receptor Modulators (Antiestrogen)IBA 10/2003
1	Indicators and Reagents (Reagents)IBA 10/2003
1	9,10-Dimethyl-1,2-benzanthraceneIBA 09/2003
1	Growth Factor ReceptorsIBA 01/2002
1	Insulin-Like PeptidesIBA 01/2002

Therapy/Procedure

5	Therapeutics 01/2015 - 05/2009
2	Subcutaneous Injections 07/2006 - 03/2006
1	Oral Administration 01/2008
1	Injections 02/2007